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Research has revealed a unique protease activation phenomenon in MELAS: LONP1 exhibits subcellular compartmentalized aggregation in primary cells from patients with MELAS, with its protein abundance particularly elevated in cell populations enriched with mutant mtDNA

Current (SGLT2 inhibitors, GLP1R agonists) and emerging therapies (NAD precursors, ketone esters) targeting metabolic pathways at both systemic and myocardial levels offer promising treatment opportunities, particularly for HFpEF

REFERENCES 1.Badon LA, Hicks A, Lord K, Ogden BA, Meleg-Smith S, Varner KJ

For more information, call the Cancer Information Service (CIS), NCI's contact center, at 1-800-4-CANCER (1-800-422-6237)

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Comparison of GH secretagogues: CJC-1295 alone (GHRH): prolonged basal stimulation